ZC3H12A and neoplasm: Although other clinicopathological features such as T stage, lymph node status and distant metastasis were not available for patients in this validation cohort, we found that ZC3H12A expression was associated with significantly longer disease-free survival (DFS) with a hazard ratio for relapse of 0.41 (95% confidence interval 0.27- 0.85; P = 0.0128, log-rank test) (Figure 2B), which is consistent with the observed association of lower ZC3H12A expression with more aggressive tumor features in the TCGA cohort.