Consistent with its tumor stage association, patients with lower ZC3H12A expression also had more aggressive tumor features in the TCGA CRC cohort, including tumor pathologic T stage (P = 0.0005), residual tumor (P = 0.033), distant metastasis (P = 0.044) and positive lymph nodes (P = 0.0008) (Figure 1B). Here, ZC3H12A is linked to colorectal carcinoma.