The ZC3H12A mRNA expression was significantly higher in stage I tumors than in stage II tumors (P = 0.0014), stage III tumors (P = 0.0004) and stage IV tumors (P = 0.0023), further confirming its predictive role as a biomarker of early-stage CRC tumors (Figure 4A). This evidence concerns the gene ZC3H12A and colorectal carcinoma.