ZC3H12A and colorectal carcinoma: Correlation of ZC3H12A expression with tumor stage showed that ZC3H12A had significantly higher expression in stage A tumors than in stage B tumors (P = 1.0E-06), stage C tumors (P = 2.8E- 06), stage D tumors (P = 1.8E-08) and stage B, C and D tumors combined (P = 6.6E-09) (Figure 2A), confirming that ZC3H12A is a robust biomarker for early-stage CRC detection regardless of gene expression measurement method.