Soluble ENO-1 was found in serum and synovial fluid of rheumatoid arthritis patients (Guillou et al., 2016) and in serum of patients suffering from lupus erythematosus (Hawro et al., 2015; Li et al., 2018), systemic sclerosis (Terrier et al., 2010; Mehra et al., 2013) and Alzheimert’s disease (Castegna et al., 2002; Butterfield and Lange, 2009; Owen et al., 2009). This evidence concerns the gene ENO1 and rheumatoid arthritis.