TGFB1 and cancer: Faouzi et al. (1999) reported that myofibroblasts are the primary source of collagen (types I, IV, V and VI) in the stroma of human hepatocellular carcinoma. In addition, CAF-derived laminin was shown to induce cervical cancer cell migration via the interaction with integrin α6β4 (Fullar et al., 2015). In an in vitro ovarian cancer spheroid model, CAF-secreted versican promoted cancer invasion in a TGF-β-dependent manner (Yeung et al., 2013).