In recent clinical trials, simtuzumab, a monoclonal antibody against LOXL2, failed to produce improved anti-tumor benefits when given in combination with other anti-cancer drugs, including 5-fluorouracil, leucovorin, irinotecan (FOLFIRI) and gemcitabine (Benson et al., 2017; Hecht et al., 2017). Here, LOXL2 is linked to neoplasm.