The induction of respiratory TRM cells in immunized mice with the OMVs vaccine is an important finding since this memory CD4 T cell population not only provide much more immediate protection than the anti-pathogen responses conferred by naïve T-cells, they also could provide more effective immune protection to the host as demonstrated in other models of infection (Teijaro et al., 2011; Glennie et al., 2017). The gene discussed is CD4; the disease is infection.