In addition, either suppressing SMYD2 activity or knocking down SMYD2 would contribute to the increases in sensitivity to CDDP, and the reduction in cell migration and self-renewal ability in CDDP-resistant NSCLC cells, indicating that SMYD2 executes a crucial role in CDDP resistance of NSCLC. This evidence concerns the gene SMYD2 and non-small cell lung carcinoma.