SMYD2 and non-small cell lung carcinoma: To explore the possible action of SMYD2 in chemotherapeutic agents in NSCLC, A549 and NCI-H460 cells were treated with various concentrations of the first-line chemotherapeutic agents, including CDDP, Taxol, NVB, and VCR, and combined treatment with SMYD2 inhibitor BAY-598 with non-cytotoxicity concentration (2 μM, cell viability>90%, Supplementary Figure 1A).