The consensus clustering results showed the presence of 4 main entities of breast cancer but, more importantly, these 4 entities were found to be very-well recapitulated by the 4 main intrinsic subtypes (Luminal A, Luminal B, HER2-E, and Basal-like) as defined by mRNA expression only (3, 5, 6, 36, 38–40). The gene discussed is ERBB2; the disease is breast cancer.