We hypothesize that upon stimulation of pro-inflammatory cytokines and growth factors, endothelial cells express TF in the early stage of RA (acute phase, for example, TF reaching peak expression at 4–6 h post VEGF stimulation, Figure 1b) and then endothelial TF expression may decrease or even disappear in later stages of RA (chronic phase, for example, TF expression started decreasing 8–24 h post VEGF stimulation) (Figure 1 in reference [15], not shown here). The gene discussed is TF; the disease is rheumatoid arthritis.