However, in tumor tissues, HK can combine with mitochondria, forming particles of HK, of which the N-terminal domain has a hydrophobic end connected to the outer mitochondrial membrane; this then forms a complex with the mitochondrial permeability tunnel complex of the voltage dependent anion channel protein (VDAC) binding to HK and forming HK-VDAC [51]. This evidence concerns the gene VDAC1 and neoplasm.