HIF1A and laryngeal carcinoma: Bruine de Bruin L (2015) evaluated the relationships of three endogenous hypoxia markers (HIF-1α, CAIX, and GLUT-1) with FAZA uptake in 11 patients with laryngeal carcinoma indicated for total laryngectomy and found positive immunostaining for GLUT-1 in all biopsies but no relationship of any of these three markers with FAZA uptake [71].