However, Kwon et al. (2014) examined the predictive values of HIF-1α, carbonic anhydrase IX (CAIX), GLUT-1, cyclooxygenase-2, Ki-67, and erythropoietin receptor in 42 tissue samples of T1/T2 early-stage laryngeal carcinomas treated with radiotherapy alone by tissue microarray analysis and IHC and found that only high CAIX was significantly associated with residual tumors on multivariate analysis [68]. The gene discussed is CA9; the disease is laryngeal carcinoma.