HIF-1, GLUT-1, and HK-II were also highly expressed in 36 cases of stage T1 and T2 squamous cell carcinoma of the oral cavity and were significantly correlated with FDG uptake; furthermore, the expression of HIF-1 was related to the expression of GLUT-1 and HK-II [133]. This evidence concerns the gene HIF1A and squamous cell carcinoma.