Kim et al. (2017) detected glycolysis markers, including GLUT-1, HK-II, CAIX, and MCT4, in 265 follicular neoplasm (FN) samples and 108 Hürthle cell neoplasm (HCN) samples by tissue microarray and IHC staining and found that these markers were highly expressed in HCNs compared with in FNs, with the highest expression in Hürthle cell carcinoma (HCC) followed by Hürthle cell adenoma, follicular carcinoma (FC) and follicular adenoma (FA), in that order (all P<0.001). This evidence concerns the gene HK2 and hepatocellular carcinoma.