In this regard, we evaluated the expression of anti-inflammatory IL10, pro-inflammatory TNFα and MSC CD73 markers within the lung and brain niches in response to systemic conditioning with metastatic and non-metastatic breast cancer cell secretomes (Figure 1A), and characterized the influence of tumor-educated derivatives of these stromal cell types on one another in vitro (Figure 3A). Here, TNF is linked to breast cancer.