Similar to many other S100 proteins, S100A14 has been shown to (i) interact with transmembrane receptors (such as RAGE, human epidermal growth factor receptor 2 (HER2 or ErbB2)) [53, 54] and other S100 protein members (for example S100A16) [36], and (ii) have a tight functional link with the tumor suppressor p53 in human cancers [10, 55] (Figure 2). The gene discussed is ERBB2; the disease is cancer.