EGF and cancer: Recently, HDACi have evolved into chimeric HDACi (chi-HDACi) which simultaneously modulate both HDAC and other targets, using molecular hybridization techniques, drugs that target protein tyrosine kinases, epidermal growth factor (EGF), BCL-ABL tyrosine kinase, or VEGFR along with HDACi were made into chi-HDACi structures which can be used to treat multiple cancer types [274].