APP and Alzheimer disease: MEF-2 also plays an important role in the Alzheimers disease, specifically amyloid precursor protein (APP)-mediated signaling pathway by inhibiting neuronal apoptosis by mediating the p38 MAPK-dependent pathway and activation of MEF-2-dependent gene transcription; alterations in this pathway results in the neuronal degeneration that occurs in Alzheimer's disease (AD) [117].