GSK3B and cancer: Some anti-cancer agents like SU4312, yielded an unexpected neuroprotective effect by potentiating the pro-survival effect of PI3-K/AKT pathway to downregulate the inhibitory effect of MEF-2D inhibitor glycogen synthase kinase-3 beta (GSK3β) and ameliorated parkinsonian motor defects and restored levels of MEF-2D [137].