Although there are many HDAC inhibitors being studied in preclinical and clinical trials, one of the unique class IIA HDACi, namely MC1568, is highly selective to class IIA HDACs and has been shown to activate the tumor suppressor BRAHMA, that is suppressed by HDAC9 and exhibits cytostatic effect in melanoma cells much greater than Class I inhibitors [275]. Here, HDAC9 is linked to melanoma.