MEF-2D is involved in cancer of the colorectal tissue, breast, prostate, lung, liver, and thyroid [124, 125].Implicated in melanoma [279–281], and pathobiology of B-cell acute lymphoblastic leukemia (B-ALL) [248].Also, Parkinson's disease, cardiac myxoma, and lung cancer [239, 244, 250, 251]. The gene discussed is MEF2D; the disease is melanoma.