MEF-2C is one of the most characterized genes in the MEF-2 family and has shown to be involved in various neural, cardiac, skeletal, muscle, lymphoid and myeloid developmental programs, and has also been implicated in various types of T-cell and B-cell lymphomas, carcinomas, many neurodegenerative diseases and vascular disorders. The gene discussed is MEF2A; the disease is neurodegenerative disease.