All cells and tissues have high levels of protein expression of MEF-2D in cerebral cortex, endocrine system, bone marrow, hematopoietic, germinal centers and also non-germinal centers, cardiac and skeletal muscles, kidneys, breast and skin, etc. MEF-2D is mainly localized in the nucleoplasm and overexpression of MEF-2D is observed in colorectal, breast, prostate, lung and liver cancers, with 100% overexpression in lymphomas, urothelial, breast, thyroid carcinomas and melanomas (https://www.proteinatlas.org/). This evidence concerns the gene MEF2D and liver cancer.