In all cancer samples there is association between PARP1 alteration, and, at least, one gene; in all the cases this association is a co-occurrence of amplification; this co-occurrence is particularly frequent for RIT1 that was found to be amplified in 6 out of 8 cancer types, suggesting a genetic interaction between their pathways and a possible common de-regulation in cancer (Figure 2A). The gene discussed is PARP1; the disease is cancer.