IDH2 and central nervous system cancer: Other loci were found altered such as Aldehyde dehydrogenase 2 (ALDH2) and isocitrate dehydrogenase 2 (IDH2), that was found to predispose to cervical carcinoma [34] and glioma [35] respectively as well as BCL3, AKT2 and ERCC2 for which polymorphisms were shown to be associated with lung carninoma [36–38].