Others loci were altered such as BRD4, EP300, H3F3A and H3F3B involved in chromatin remodeling recreating, when mutated, a hallmark of chondroblastoma and giant cell tumor of bone [22] in addition to JAK3, ASXL1 and ELL that confers, once altered, features of megakaryoblastic leukemia [23], myelodysplastic syndromes [24] and acute promyelocytic leukemia [25] respectively. This evidence concerns the gene EP300 and adult acute megakaryoblastic leukemia.