ALPP and melanoma: In contrast we identified more than 50 different loci of cancer-associated alterations mainly in teratoma generated with early passage (<20) of hiPSCs produce by integrative vectors which results in the emergence of malignant tumors within the teratoma such as an invasive carcinomas positive for c-Myc or for PLAP and c-kit which are frequently associated with gastrointestinal stromal tumors [47] and melanoma [48].