CENPE and cancer: Our work focused on newly formed MNi specifically arising from merotelically attached LCs (most common chromosome segregation defect in cancer cells [21, 22]), as opposed to other studies that examined the behavior of MNi arising as a result of DNA damage [10, 11] or studies that analyzed MNi derived from other mitotic defects (e.g., unaligned chromosomes from CENP-E inhibition [19]) or a combination of mitotic defects (i.e., a mix of chromosome bridges, LCs, and unaligned chromosomes resulting from MPS1 inhibition [19]).