TP53 and cancer: In the pathway enrichment analysis, metabolic pathways, p53 signaling pathway, and cell cycle were identified for the upregulated DEGs, while the downregulated DEGs were associated with pathways such as PI3K-Akt signaling pathway, MAPK signaling pathway, and signaling pathways regulating pluripotency of stem cells and proteoglycans in cancer (Figure 2B and Supplementary Table S5).