To investigate in vitro the role in MH of PLAUR, the most DPG-activated gene during the recovery phase from colitis at 6 h, as well as its ligand VTN, we observed the ability to repair and barrier function recovery of intestinal epithelial cells, exposed in time order to cytomix and DPG, in which VTN and PLAUR were alternately inhibited by specific antibody. This evidence concerns the gene PLAUR and colitis.