Chronically infected mice exhibited a higher percentage of T cells that produce TNF-α than acutely infected mice, and late chronically infected mice showed a higher proportion of cytotoxic CD8+ T cells producing granzyme B and perforin than infected mice at 100 dpi, suggesting that our results are similar to previous studies and correlated with the severity of ChD. The gene discussed is GZMB; the disease is coronary artery disorder.