By finding a down-regulated gene expression of Drosha and DGRC8 just in non-lesional skin from HS patients, the authors hypothesized an early intervention of these miRNA regulators during the first, clinically and histologically not detectable, stages of inflammation, thus suggesting that when inflammation signs become observable only at that moment Dicer and Exportin-5 are involved. The gene discussed is XPO5; the disease is histiocytic sarcoma.