Initially, these genes include CD19 (16), CD20 (17), CD21 (18), CD81 (19), ICOS (20), TACI (21), BAFFR (22), however, recently more genes have been associated with CVID such as TWEAK, CD27, IL21, IL21R, LRBA, CTLA4, PI3KCD, IKAROS, NFKB1, NFKB2, PRKCD, PIK3R1, VAV1, RAC2, BLK, and IRF2BP2 (23–25). This evidence concerns the gene NFKB2 and common variable immunodeficiency.