STAT3 and common variable immunodeficiency: Interestingly, CVID patients with normal percentages of unswitched memory and switched memory B cells had similar methylation levels than healthy counterparts for CpGs at the AICDA, FOXO, AKT1, NFKB2, and STAT3 genes, in which these CpGs underwent demethylation to a similar extent to B cells from healthy individuals.