The results indicated the shorter median PFS and OS were associated with low histologic grade, advanced stage, lymph node metastasis, residual disease ≥1 cm, VEGF positive expression, SEMA4D positive expression, PD-L1 positive expression, and patients' response to BC (all of them P < 0.05, Table 5). The gene discussed is SEMA4D; the disease is metastatic malignant neoplasm in the lymph nodes.