By down-regulating p65 in the tumor cells and/or in the MSCs, we demonstrated that in the absence of p65 activation in both cell types together, the expression of Notch1 (FL-Notch1) was significantly reduced, in the presence of TNFα stimulation (Figures 9A,B1; lanes 5 vs. 8) and in its absence (Figures 9A,B1; lanes 1 vs. 4). The gene discussed is RELA; the disease is neoplasm.