Next, p65 was knocked-down in the MSCs by siRNA and was knocked-out in the tumor cells by CRISPR/Cas9, leading to efficient reduction in p65 expression and activation in both cell types (Supplementary Figures 4B,C; although p65 activation was not down-regulated completely in MSCs, it was sufficient to clearly reveal the mechanistic roles of p65 in the studied processes, as shown below). The gene discussed is RELA; the disease is neoplasm.