In view of the fact that CXCL8 was revealed in our accompanying study as key regulator of many of the pro-metastatic activities of this network (26), the “take home message” of this study is that the interactions between the TNBC cells and the stromal cells have set the conditions that enabled TNFα to bring its effects to maximum, partly through p65-induced Notch1 activation that has led to CXCL8 induction, and consequently to other tumor-promoting activities. This evidence concerns the gene NOTCH1 and neoplasm.