Specifically, when tumor cells interacted with MSCs in “Contact” conditions in the absence of TNFα stimulation, they exchanged soluble materials and formed physical contacts that together led to CXCL8 induction, beyond the levels produced by each cell type alone and above the levels obtained in “Transwell” conditions in the absence of TNFα [(26); Supplementary Figure 2A1]. Here, CXCL8 is linked to neoplasm.