Also, our findings indicate that NF-κB-induced Notch1 activation is a key regulator of inflammation-driven TNBC-stromal contacts that lead to elevated release of the pro-metastatic chemokine CXCL8; as we have shown before, CXCL8 then contributed to elevated angiogenesis, tumor cell migration and tumor cell invasion in the tumor-stroma-inflammation network in TNBC (26). Here, NOTCH1 is linked to neoplasm.