Although our findings demonstrated that our cHA-based Prime-LAIV-LAIV and Prime-LAIV-IIV vaccination regimens induced stalk-specific humoral immunity and cellular immunity (Figure 9, Figure S7) which conferred cross-protection against influenza virus infection, the results obtained with this animal model of influenza, while encouraging, have yet to provide a good correlation between any immune readouts and protection. The gene discussed is TCFL5; the disease is influenza.