TNF and obesity due to melanocortin 4 receptor deficiency: In addition, PC1 and PC3 was positively correlated with the protective parameters, including serum adiponectin/body weight, adiponectin mRNA in eAT, cecal acetate, and cecal butyrate, whilst negatively correlated with obesity and inflammation parameters, including body weight gain, AUC of OGTT, fasting blood glucose, serum LBP, eAT adipose size, eAT CLS, eAT MMP-12, eAT TNF-α mRNA, MCP-1 mRNA, CD11c mRNA, leptin mRNA, liver TNF-α mRNA, and jejunum TNF-α mRNA (Figure 4B).