SIRT1 and Hepatic steatosis: Considering our previous finding that TSF induces renal autophagy and the critical role of autophagy in hepatic steatosis progression (Zhao et al., 2017), we aimed to explore the effect of TSF on hepatic steatosis and investigate the underlying mechanism by assessing the potential roles of autophagy and the AMPK/SIRT1 pathway, in particular.