CNTF and myeloid sarcoma: Also, a link to earlier onset of MS has been questioned (Giess et al., 2002; Hoffmann et al., 2002a,b; Linker et al., 2009); although CNTF-KO mice seem to develop earlier and more severe symptoms in experimental autoimmune encephalomyelitis (EAE) model of MS (Linker et al., 2002).