Similar to the effect of B2 blockade, injection of a specific TRPV1 blocker into the kidney of cisplatin-induced renal failure rats restored the baroreflex control of RSNA indicating an important contribution of TRPV1 in mediating an aberrant response from the injured kidney leading to blunted baroreflex control (Abdulla et al., Unpublished Data). The gene discussed is TRPV1; the disease is Renal insufficiency.