Interestingly, exercise did not modify the plasma adiponectin content in any of its isoforms (LMW or HMW), which conflicts with some previous studies that associate hypoadiponectinaemia with obesity (Weyer et al., 2001; Di Chiara et al., 2012; Prakash et al., 2013). Here, ADIPOQ is linked to obesity due to melanocortin 4 receptor deficiency.