In another study (Liu et al., 2006), microsphere mediated delivery of a combination of BDNF (25 μg) and bFGF (100 μg) was more efficacious as compared to bFGF alone (100 μg) in increasing blood flow and fractional shortening, in dogs following experimental myocardial infarction. This evidence concerns the gene BDNF and myocardial infarction.