According, periodontal disease significantly increased hypertension risk in age <40 years group (OR = 1.69), BMI normal (OR = 1.29) and abnormal groups (OR = 1.40), FBG normal group (OR = 1.35), TC normal group (OR = 1.37), TG normal group (OR = 1.45), LDL-C normal (OR = 1.25) and abnormal groups (OR = 1.58), HDL-C normal group (OR = 1.33), ESR normal (OR = 1.26) and abnormal groups (OR = 2.09), CRP normal group (OR = 1.34), UN normal group (OR = 1.35), UA normal group (OR = 1.35), creatinine normal group (OR = 1.36) and proteinuria negative group (OR = 1.35), with p < 0.05 for all. The gene discussed is CRP; the disease is periodontal disorder.