As we know, both ESR and CRP reflect the degrees of inflammation; hence, in the presence of abnormal ESR, the risk of hypertension associated with periodontal disease was significantly increased from 1.28 to 2.09; while facing abnormal VRP, the risk of hypertension related to periodontal disease was raised from 1.28 to 1.78. The gene discussed is CRP; the disease is periodontal disorder.