Studies involving behavioral tests in animal models have suggested that the sEH inhibitor 1-[1-propionylpiperidin-4-yl]-3-[4-(trifluoromethoxy) phenyl] urea (TPPU) had antidepressant effects because the inflammation and chronic social defeat stress-induced depression-like behavior was prevented by oral administration or chronic intake of TPPU (Ren et al., 2016). Here, EPHX2 is linked to depressive disorder.