SOCS1 and systemic lupus erythematosus: Reduced expression of SOCS1 and/or increased IFN-γ/IL-6 signaling are rampant in SLE rodent models and human patients (Baechler et al., 2003; Fujimoto, 2004; Harigai et al., 2008; Sharabi et al., 2009; Sukka-Ganesh and Larkin, 2016).