STAT3 (also known as acute phase response factor) is DNA-binding, an intracellular signaling protein that has pleiotropic effects on embryogenesis, oncogenesis, tumor suppression, cell differentiation, growth, and both innate and adaptive immunity (Akira, 2000; de la Iglesia et al., 2008, 2009). The gene discussed is STAT3; the disease is neoplasm.