PTK2 and neoplasm: There is increasing evidence that FAK autophosphorylation at Y397 is associated with oncogenesis by aiding in cell migration, FAK activity can lead to turnover of focal adhesion points and upregulation of MMPs, and the inhibition of the autophosphorylation has been shown to reduce tumor growth (Sieg et al., 2000; Hauck, 2002; Dunty et al., 2004; Cui et al., 2006; Hochwald et al., 2009; Heffler et al., 2013).