SOCS1 and melanoma: Epigenetic inactivation due to CpG methylation of SOCS1 is frequently linked to Hepatocellular carcinoma, human gastric carcinoma, melanoma, multiple myeloma, pancreatic ductal neoplasm, and acute myeloid leukemia (Franke, 2001; Yoshikawa et al., 2001; Chen et al., 2003; Fukushima et al., 2003; Galm, 2003; Oshimo et al., 2004; Mottok et al., 2007; Liu S. et al., 2008).