SOCS-1, being a classical regulator of JAK/STAT signaling, is a potent tumor suppressor as aberrant SOCS1 gene methylation and allelic mutations have been linked to different types of malignant cancers (Fujitake et al., 2004; Melzner, 2005, Melzner et al., 2006). This evidence concerns the gene SOAT1 and neoplasm.