SOCS1 and melanoma: Nonetheless, there are also contradicting reports that suggest increased SOCS1 expression as an accomplice in melanoma, colorectal cancer, breast cancer, and neuroendocrine cancer (Raccurt et al., 2003; Li et al., 2004; Laner-Plamberger et al., 2013; Tobelaim et al., 2015; Berzaghi et al., 2017).