SOAT1 and systemic lupus erythematosus: SOCS1 deficiency or dysregulated JAK/STAT signaling has been correlated with a number of immune disorders in humans, including SLE, scleritis, and asthma (Lee et al., 2009; Wang et al., 2010; Yu et al., 2011; Sukka-Ganesh and Larkin, 2016).