Besides influence on vascular tone, AT1 activation is involved in different pathophysiologic processes, including neurodegenerative diseases, neuronal injury, and cognitive disorders (Saavedra et al., 2004; Villapol et al., 2012; Villar-Cheda et al., 2014; Trigiani et al., 2018). The gene discussed is AGTR1; the disease is neurodegenerative disease.