AT1 activation is also involved in different pathophysiological neuronal alterations, including neurodegenerative diseases, neuronal injury and cognitive disorders (Culman et al., 2002; Saavedra et al., 2004; Timaru-Kast et al., 2012b; Villapol et al., 2012; Ongali et al., 2014; Villar-Cheda et al., 2014; Hamel et al., 2016; Trigiani et al., 2018). Here, AGTR1 is linked to neurodegenerative disease.