Cerebral ischemia could induce significant decreases in hippocampal GluN2A and GluN2B as early as 30 min, which may continue for several days (Zhang et al., 1997; Hsu et al., 1998; Dos-Anjos et al., 2009a,b; Liu et al., 2010; Fernandes et al., 2014; Han et al., 2016). Here, GRIN2B is linked to brain ischemia.