GRIK2 and brain ischemia: Tat-GluK2-9c, a fusion peptide containing the Tat peptide and C-terminus peptide of GluK2, could interfere with the interaction of GluK2 with PSD-95 and suppress the formation of the GluK2-PSD-95-MLK3 triplicate complex, thereby preventing brain injury caused by cerebral ischemia (Pei et al., 2006).