Thus, tPA is involved in several physiological and pathological CNS processes, including corticogenesis, neuronal survival, learning and memory, anxiety, epilepsy, stroke and Alzheimer's disease (Qian et al., 1993; Baranes et al., 1998; Madani et al., 1999; Pawlak et al., 2003; Alvarez et al., 2013; Oh et al., 2014; Hébert et al., 2017; Pasquet et al., 2018). Here, PLAT is linked to early-onset autosomal dominant Alzheimer disease.