However, GW9508 activation of FFAR1 in a mouse model of AD, based on Aβ intracerebroventricular (icv) injection, leads to significant improvement in cognitive and behavioral tests, what seems to be mediated by CREB phosphorylation and the concomitant increase in expression of NGF and BDNF neurotrophic factors. Here, BDNF is linked to Alzheimer disease.