SIRT2 and nervous system disorder: SIRT2 appears to play a detrimental role in neurological disorders such as PD (Outeiro et al., 2007; Chen et al., 2015), Huntington’s disease (Luthi-Carter et al., 2010) and ischemic stroke (Krey et al., 2015; Xie et al., 2017; She et al., 2018; Wu et al., 2018), and it is important to understand how SIRT2 is regulated since we know little about it.