Accumulation of aggregated tau is a hallmark of AD and related tauopathies and the accumulation of alpha-synuclein (aSyn) aggregates is the hallmark of PD and related synucleinopathies (Brion et al., 1985, 1986; Kosik et al., 1986; Wood et al., 1986; Wischik et al., 1988; Spillantini et al., 1997; Baba et al., 1998; Bayer et al., 1999). This evidence concerns the gene MAPT and Alzheimer disease.