MAPT and neurodegenerative disease: The deposition of hyperphosphorylated tau in insoluble filaments in the brain is a pathological hallmark not only of AD but also of related neurodegenerative diseases, known as tauopathies, including frontotemporal dementias (FTD) like Pick's Disease and argyrophilic grain disease, progressive supranuclear palsy, and corticobasal degeneration (Grundke-Iqbal et al., 1986b).