MAPT and Pick disease: Interestingly, the truncation at D421 is not only found in AD brains, but also in Pick's disease brains, where C-terminal truncated tau has been proposed to be the main isoform found in exosomes (Mena et al., 1995; Gamblin et al., 2003; Basurto-Islas et al., 2008; Mondragon-Rodriguez et al., 2008; Kanmert et al., 2015).