Although in microglia/macrophages CD40 is regarded as M1 marker (Aarts et al., 2017), it was evidenced that about 70% of CD40 positive microglia/macrophages in MS lesions coexpress markers of M2 phenotype, indicating frequent CD40 association with mixed M1/M2 phenotype (Vogel et al., 2013). The gene discussed is CD40; the disease is myeloid sarcoma.