Fly models for these diseases are generated by mis-expression of human proteins that are neuropathological hallmark lesions in brains of patients with PD (α-synuclein), AD (tau), frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (TDP-43) (Feany and Bender, 2000; Wittmann et al., 2001; Jackson et al., 2002; Li et al., 2010). This evidence concerns the gene MAPT and Alzheimer disease.