To test whether anti-tumor activity of 3H3-mIgG2a could be restored by blocking FcγR-mediated ADCC, we generated 3H3-mIgG2a with FcγR-binding null mutations D265A and N297A (DANA), resulting in Abs unable to bind any FcγRs27. This evidence concerns the gene FCGR2A and neoplasm.