For example, NMDA treatment damages retinal neurons and was used to establish a zebrafish glaucoma model, while the gnn mutant or vascular endothelial growth factor (VEGF) treatment lead to AMD characteristics similar to those seen in human AMD [30,37,76,77].We postulate that in aging zebrafish retinas the high demand for nutrition and energy will activate mTOR, which promotes mitochondrial fission to increase ATP production and suppresses fusion to compensate for the decreasing mitochondrial function. This evidence concerns the gene VEGFA and age-related macular degeneration.