MSH6 and neoplasm: Additionally, five missense variants of unknown significance were detected in tumor tissue only, one in MSH2 (c.2198C>A; p.(Ala733Asp)) and four in MSH6 (c.821G>A; p.(Ser274Asn), c.1730G>A; p.(Arg577His), c.2419G>A; p.(Glu807Lys) and c.3163G>A; p.(Ala1055Thr)).