Plaques formation is a major event in atherosclerosis related activation of macrophages and proliferation of VSMCs.1, 2 To gain a better understanding of the aberrant VSMCs proliferation in atherosclerotic plaque formation, we established atherosclerosis model as described previously,21 which was characterized by a markedly increased atherosclerotic lesions in aortic root and serum Hcy levels in APOE−/− mice fed with high‐methionine diet as well as a significant positive correlation between serum Hcy levels and atherosclerotic lesions (Figure 1A‐C). Here, APOE is linked to atherosclerosis.