Similar results were also found in cancer cells, where MFN2 exert an anti‐proliferative effect by inducing cell cycle arrest in the G0/G1 phase via inhibition of Ras‐Raf‐ERK1/2 signalling pathway.38 These previous observations and this study suggest that Hcy can promote proliferation of VSMCs during the formation of atherosclerotic plaque, which is at least partially dependent on the down‐regulation of MFN2 expression. Here, MAPK3 is linked to cancer.