The p53 status of these two cell lines (PC3 being p53‐null, and LNCaP containing wild‐type p53) might also contribute to the different radio‐sensitivities observed in our experiments, given the important roles of p53 in double‐strand break response and DNA repair.45 While further experiments would be required to test this hypothesis, the available evidence suggests that any radiosensitizing effect of EZH2 inhibition in the PCa cell lines tested is modest. Here, EZH2 is linked to posterior cortical atrophy.