Radical total thyroidectomy was done in January 2015 and verified multifocal papillary carcinoma (mixed follicular variant and focal insular/solid variant) 8.4 × 4.3 × 4.0 cm in size with lymphovascular invasion and extrathyroid extension to the muscle (Additional file 1: Figure S1), negative for BRAF V600E gene mutation. This evidence concerns the gene BRAF and papillary carcinoma.