CRB1 and retinitis pigmentosa 1: Indeed, mutations in CRB1 gene cause a spectrum of hereditary retinal dystrophies, including LCA type 8 (LCA8), early-onset rod-cone dystrophy, RP12, autosomal dominant pigmented paravenous chorioretinal atrophy, recessive RP with para arteriolar preservation, CRD, and isolated autosomal recessive foveal retinoschisis[8,9,27-30].