In analyses where IMT was the marker of atherosclerosis, histidine, N,N-dimethylglycine, and albumin showed strong inverse associations below the MWSL threshold (P = 7 × 10−7 to 6.7 × 10−6); 14 other metabolites retained nominal statistical significance (P < 0.05). The gene discussed is ALB; the disease is atherosclerosis.