Based on our findings, the anti-proliferative activity of AZD2461 was clearly observed in cells expressing significantly lower mRNA levels of PTEN. Thus, PARP inhibition can be regarded as a beneficial therapeutic strategy not only in BRCA1/2-deficient cells but also in Pca cells displaying low PTEN baseline expression due to their genetic backgrounds. Here, BRCA1 is linked to posterior cortical atrophy.