REC8 and neoplasm: Also, an investigation of genetic and epigenetic alterations in paediatric GC tumours concluded that most studied tumours derived from pre‐meiotic PGCs and only in a few cases tumours appear to have arisen from errors during meiosis (Ichikawa et al., 2013), although the UPD observed in some of these tumours could also be explained by aberrant development of monopolar centromeres by activation of REC8, for example (see above), and not by a meiotic error per se.