Angiogenesis not only provides the tumor with oxygen and essential nutrients but also promotes the spread and proliferation of cancer cells.14 Angiogenesis is a complex, multi‐step process involving extracellular matrix remodeling, migration and proliferation of endothelial cells, and capillary formation.15 VEGF is the prototypical angiogenic stimulating molecule that has been implicated in several steps of the angiogenic process. The gene discussed is VEGFA; the disease is cancer.