IL‐1RA has been connected with a variety of diseases, including cardiovascular disease, type II diabetes, carcinoma, and joint diseases.8, 9, 10 IL‐1RA can inhibit angiogenesis by blocking the activation of the IL‐1α/PI3K/NF‐κB pathway in IL‐1‐producing human colon cancer cells.11 Downregulation of IL‐1RA is correlated with the metastatic potential of gastric cancer through blockage of the IL‐1α/VEGF signaling pathways.12 IL‐1RN was confirmed to be downregulated in ESCC.13 However, the mechanism and function of IL‐1RA remains unclear. Here, IL1A is linked to esophageal squamous cell carcinoma.