VEGFA and carcinoma of esophagus: Increasing VEGF expression is directly proportional to increasing tumor growth and metastasis by promoting angiogenesis and increasing vascular permeability.16 The role of VEGF in angiogenesis was further confirmed by the effects of hypoxia and several indirect effects of pro‐angiogenic factors, which were able to further increase the synthesis of VEGF.17, 18 It is important that VEGF has also been associated with tumor progression by stimulating angiogenesis in human esophageal carcinoma.19, 20